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loss of function mutation

mutation that causes a decrease in or elimination of a gene product's activity

en-GB/ˈlɒs əv ˈfʌŋkʃn mjuːˈteɪʃən/
en-US/ˈlɔs ʌv ˈfʌŋkʃən mjuˈteɪʃən/

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mutation