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Major depressive disorder

all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities

Pronunciation
/ˈmeɪʤə dɪˈprɛsɪv dɪsˈɔːdə/
/ˈmeɪʤər dəˈprɛsɪv ˌdɪsˈɔrdər/